Research Project "Biotechnology of New Materials"

Years: 2010–2012
Keywords: biopolymers, polyhydroxyalcanoates, tissueengineering, drugdelivering
Contacts:
  • Sergey Verkhovets — Vice-rector for research and international cooperation
    dia [at] sfu-kras [dot] ru
  • Sergey Pervukhin — Head of Science and Innovation dept
    spervukhin [at] sfu-kras [dot] ru
  • Anthony Sinskey — Leading Scientist
  • Ekaterina Shishatskaya — Project manager
    shishatskaya [at] inbox [dot] ru
Site: biotech.sfu-kras.ru

The project “Biotechnology of New Materials” of the SibFU School of Fundamental Biology and Biotechnology has won the competition for the grant of the Russian Federation Government within the framework of the governmental program to support research in Russian higher education institutions supervised by the world leading scientists. The project is focused on the establishment of the Center of Biotechnology Excellence at Siberian Federal University; it includes fundamental research, educational and innovative activities in the field of biotechnology of new biomaterials. The project is fulfilled by the Basic Chair of Biotechnology involving the Chair for Medical Biology and the Chair for Biophysics of the School of Fundamental Biology and Biotechnology of Siberian Federal University.

The project is supervised by the leading scientist Prof. Anthony J. Sinskey, world-famous in the field of biotechnology. Prof. Sinskey has significant experience in research and realization of his research ideas in the field of metabolic engineering focusing on fundamental physiology, biochemistry and molecular genetics of the important organisms. In the Lab of New biomaterials in SibFU we are producing new biopolymers, investigating their properties and developing innovative applications, our topic is degradable polymers of microbial origin — polyhydroxyalkanoates (PHAs), Bioplastotan. This type of biodegradable and environmentally friendly plastic is an alternative to chemical polymers and can be used for biopackage, agriculture and etc., also they are matching for various applications in medicine, as an long-term biodegradable implants, scaffolds for bioartificial tissues and organsand nano- and micro carriers in targeted drug-delivering systems.

Publication

  • Tatiana G. Volova, Ekaterina I. Shishatskaya, Anthony J. Sinskey «DegradablePolymers: Production, Properties, Applications»ISBN: 978-1-62257-832-0
  • A. V. Murueva, E. I. Shishatskaya,
A. M. Kuzmina, T. G. Volova, A. J. Sinskey. Microparticles preparedfrombiodegradable polyhydroxyalkanoates asmatrixforencapsulationofcytostaticdrug.JMaterSci: MaterMed 
DOI 10.1007/s10856-013-4941-2 April 2013, SpringerScience.
  • Brigham C. J., Zhila N., Shishatskaya E., Volova T. G., Sinskey A. J. Manipulation of Ralstoniaeutropha carbon storage pathways to produce useful bio-based products . SubcellularBiochemistry. Bookchapter; Series “Reprogramming microbial metabolic pathways”. 2013
  • T. G. Volova, A. N. Boyandin, A. D. Vasiliev, V. A. Karpov, S. V. Prudnikova, O. V. Mishukova, U. A. Boyarskikh, M. L. Filipenko, V. P. Rudnev, Bui Ba Xuan, Vu Viet Dung, I. I. Gitelson Biodegradation of polyhydroxyalkanoates (PHAs) intropical coastal water sand identification of PHA-degradingbacteria // PolymerDegradationandStability. – 2010. -V. 95.- P.2350-2359 (IF 2.154)
  • Slabko V. V., Volova T. G., Krasnov P. O., Kuzubov A. A., I. Shishatskaya E. I. Surface Modification of Bioresorbable Polymer Scaffolds by Laser Treatment/ Biophysics. 2010-V. 55, No 2. Pp. 277-283;
  • T. G. Volova, A. N. Boyandin, A. D. Vasiliev, V. A. Karpov, S. V. Prudnikova, O. V. Mishukova, U. A. Boyarskikh, M. L. Filipenko, V. P. Rudnev, Bui Ba Xuan, Vu Viet;
  • Dung, I. I. Gitelson Biodegradation of polyhydroxyalkanoates (PHAs) in tropical coastal waters and identification of PHA-degrading bacteria /Polymer Degradation and Stability. 2010-Vol. 95. P.2350-2359;
  • Shishatskaya E. I., Goreva A. V., Kalacheva G. S., Volova T. G. Biocompatability and resorption of intravenously administered polymer microparticles in tissues of internal organs of laboratory animals// J. Polym. Sci: Polym. Ed.-2010. Appeared or available online: 10 November 2010;
  • Mogilnaya, O. A., Puzyr, A. P. , Baron, A. V., Bondar V. S.Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds// Nanoscale Research Letters, 2010-Volume: 5, Issue: 5, Pages: 908-912;
  • Purtov, K. V., Petunin, A. I., Burov, A. E., Puzyr, A. P., Bondar, V. S Nanodiamonds as Carriers for Address Delivery of Biologically Active Substances// Nanoscale Research Letters, 2010-Volume: 5, Issue: 3, Pages: 631-636

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